(P 467) DOES PERIOPERATIVE RADIATION AFFECT IMPLANT SURVIVORSHIP OF PRIMARY TOTAL HIP ARTHROPLASTY IN THE SETTING OF METASTATIC BONE DISEASE: A MULTICENTER STUDY

Objective: Metastatic bone disease (MBD) commonly affects the hip and surgical intervention including total hip arthroplasty (THA) is often indicated to treat the joint and improve function. Patients with metastatic cancer often receive radiotherapy and orthopedic oncologists must consider surgical risks with operating on irradiated bone and soft tissue. We evaluated surgical outcomes and implant survival of titanium acetabular components in patients treated for MBD in the setting of perioperative radiation.

Methods: This was a retrospective review of patients who underwent THA for MBD at three institutions between 2017 and 2021. Outcomes included rates of reoperation, complications, implant survival (IS), and overall survival.

Results: Forty-six patients who received primary THA for MBD were included in the study. Twenty patients (43.5%) received perioperative radiation for MBD. Six postoperative complications including one superficial wound infection, two dislocations, two pathologic fractures and one aseptic acetabular component loosening led to five reoperations. There were no significant differences in postoperative outcomes, reoperation after THA, and IS based on radiotherapy status.

Conclusion: To our knowledge, this is the first paper evaluating primary THA outcomes and IS between patients who receive perioperative radiation for MBD to the hip and those who do not. As surgical management is a crucial part of the treatment in alleviating pain and disability in patients with MBD, we continue to recommend THA for patients who received radiation to the operative site.