Assistant Professor
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
The Cillo Lab focuses on addressing fundamental questions about how immune cells make cell fate decisions, how intercellular communication influences these cell fate decisions, and the ways in which cell-cell interactions shape community dynamics in the tumor microenvironment. We are approaching these questions in three major ways: i) Translational studies: applying high-dimensional approaches including spectral flow cytometry, single-cell multi-omics and spatial transcriptomics as part of translational studies in patients with solid tumors; ii) Mechanistic models: development of in vitro models focused on dissecting specific aspects of cellular differentiation and intercellular communication; and iii) Computational approaches: developing, validating, and implementing computational tools to study cell-type specific drivers of differentiation and intercellular communication in vitro and in vivo. By implementing these three approaches, we will define the contributions of individual immune populations to antitumor immunity as well as their aggregate behavior within the tumor microenvironment in patients. Better understanding the individual and community dynamics of immune populations will allow us to dissect why current immunotherapies fail in some patients and it will enable identification of new therapeutic strategies to promote antitumor immunity.
Disclosure information not submitted.
Friday, November 3, 2023
10:00 AM – 11:00 AM
