.jpg "Harjeet Singh, PhD photo")
Assistant Professor
The University of Texas MD Anderson Cancer Center
Dr Harjeet Singh is an Assistant Professor in the Department of Pediatrics at UT MD Anderson Cancer Center with 15 years of experience as a translational investigator in development and application of novel immunotherapeutic modalities for hematological malignancies and solid tumors. Dr. Singh's primary focus in enhancing the body's natural defenses against cancer has bridged the gap bringing innovative treatments from the bench to the bedside.
One of Dr. Singh's most notable achievements has been his work on arming immune cells with chimeric antigen receptors (CARs), using a cutting-edge non-viral gene transfer approach—Sleeping Beauty system— that redirects these cells' specificity towards cancer cells. This breakthrough has provided hope to countless patients in clinical trials at MD Anderson. Furthermore, Dr. Singh's research extends to cytokine co-stimulation to enhance NK cell and T-cell activation and persistence. This is important in treating disease, preventing relapse and demonstrates T-cell memory phenotype can significantly augment the longevity of the anticancer effects of adoptive CAR T-cell therapy.
Dr Singh is also at the forefront of tailoring immunotherapies for solid tumor patients by reprogramming tumor-infiltrating lymphocytes (TILs) and identifying neo-antigen specific T-cell receptors (TCRs), a crucial step in personalizing immunotherapies. His approach has the potential to transform cancer treatment by targeting the specific genetic characteristics of each patient's tumor improving the effectiveness of immunotherapy.
In addition to his individual accomplishments, Dr. Singh’s collaborative spirit has fostered partnerships with experts, leveraging their collective knowledge to push the boundaries of immunotherapy. Notably, research projects focused on single-cell analysis using high-throughput time-lapse imaging microscopy, coupled with multi-dimensional bioinformatics, which provide deeper insights into the intricate workings of the immune system.
Dr. Harjeet Singh's commitment to immunotherapy has actively facilitated the transition of pioneering treatments from the research setting to practical application for the benefit of patients.
