Hepatopancreatobiliary Surgical Oncology
OHSU Knight Cancer Institute
Dr. Skye Mayo is board certified in both Complex General Surgical Oncology and in General
Surgery. His clinical practice serves patients with tumors of the liver, bile ducts, and pancreas.
He also treats patients with gall bladder cancer, cancers of the stomach and digestive system,
and retroperitoneal sarcomas. His research focuses on helping patients with cancers that have
spread to the liver, such as colorectal cancer, or arise within the liver, such as, intrahepatic
cholangiocarcinoma and other biliary tract cancers.
Dr. Mayo is an Oregon native, born in Eastern Oregon and raised in Central Oregon. During his
surgical residency at Johns Hopkins his clinical and research work focused on the treatment of
patients with pancreatic and liver cancers. He completed a research fellowship in Cancer
Immunology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins investigating
the role of immune therapy in patients with metastatic liver disease. His surgical oncology
fellowship at Memorial Sloan-Kettering Cancer Center in New York was focused in advanced
Hepatopancreatobiliary Surgery where he was also certified to perform robotic cancer
operations.
He is a member of a talented team of surgeons and oncologists at OHSU where he uses his
experience and research to help advance the treatment of patients with cancers of the liver,
bile ducts, and pancreas. His research at OHSU involves using hepatic arterial infusion pump
(HAI) regional therapy for patients with liver and bile duct cancers through the development of
early phase investigator-initiated trials which he leads. His scientific collaborative research
efforts are directed toward the early detection of recurrent cancer and monitoring responses to
treatment in patients with colorectal cancer metastatic to the liver and in patients with biliary
tract cancers such as intrahepatic cholangiocarcinoma.
