(P 377) EFFECTIVENESS OF INTERVENTIONAL RADIOLOGY GUIDED PROCEDURES FOR LOCALLY RECURRENT AND METASTATIC SARCOMA: SINGLE INSTITUTIONAL RESULTS

Objective: Musculoskeletal image guided interventional radiology (IR) techniques have grown popular in the management of sarcoma. Thermal ablation and nonthermal ablative techniques are minimally invasive, targeted treatment modalities for sarcoma that can be seamlessly integrated into neoadjuvant or adjuvant treatment regimens. We report our institutional cohort of metastatic and recurrent sarcomas treated by IR.

Methods: From 2013 to 2022, 24 patients who received an ablation procedure for recurrent or metastatic sarcoma at our institution were retrospectively reviewed. Patient’s sarcoma treatments including surgical resection, chemotherapy and radiotherapy, ablation modality, postprocedural complications, ablated lesion progression, and clinical course were collected from the medical records.

Results: Sixteen patients were treated with ablation for metastatic sarcoma and eight patients were treated with ablation for locally recurrent sarcoma. Median size of the ablated lesion was 2.7 cm (IQR 1.75-4.43). Lesion progression was observed in 2 of 24 ablated lesions at median 8 months, both in ablated locally recurrent sarcoma. Four patients developed complications including nerve pain, hemoptysis, infected hematoma, and necrotic wound requiring debridement.

Conclusion: We report high levels of local control of the ablated lesions in our cohort with minimal post-procedural complications. Future multi-institutional studies should evaluate the efficacy of ablation techniques in a more uniform cohort.