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Session 12: Preclinical Models and Translational Research

Saturday, November 4, 2023
11:30 AM – 1:00 PM  

    Chair(s)

  • Rebecca Gladdy, MD, PhD (she/her/hers)

    Surgical Oncologist Clinician-Scientist Associate Professor of Surgery
    Mount Sinai Hospital, Sinai Health System, and Princess Margaret Cancer Centre Toronto, ON, Canada Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada University of Toronto, Toronto, ON
    Toronto, Ontario, Canada

    • Moderator(s)

  • SP

    Sandro Pasquali, MD, PhD

    Fondazione IRCCS Istituto Nazionale dei Tumori
    Milan, Lombardia, Italy

  • AB

    Ana Banito, PhD

    Assistant Professor
    Hopp Children's Cancer Center, German Cancer Research Center
    Hedielberg, Baden-Wurttemberg, Germany

  • Brian Van Tine, MD, PhD (he/him/his)

    Professor of Medicine
    Washington University School of Medicine
    St. Louis, Missouri, United States

Presentations:

  • 11:30 AM – 1:00 PM  
    THE EIF4A1/2 INHIBITOR CR-1-31B DOWN-MODULATES THE ANTIOXIDANT RESPONSE AND INHIBITS LUNG METASTASIS IN OSTEOSARCOMA

    Author: Michael M. Lizardo, PhD – BC Cancer, Provincial Health Services Authority

    Co-Author: Christopher Hughes, Ph.D. – BC Cancer

    Co-Author: Yue Zhou Carol, B.Sc. – BC Cancer

    Co-Author: Alberto Delaidelli, Ph.D., M.D. – BC Cancer

    Co-Author: Taras Shyp, M.D. – BC. Cancer

    Co-Author: Haifeng Zhang, PhD – BC Cancer

    Co-Author: Sol Snir Shaool (he/him/his) – UVic

    Co-Author: Leanne Sayles, BS – UCSF

    Co-Author: Alejandro Sweet-Cordero, MD – UCSF

    Presenter: Poul H. Sorensen, PhD, MD – BC Cancer, part of PHSA

  • 11:30 AM – 1:00 PM  
    UCHL5 GUARDS AGAINST REPLICATION STRESS IN PAX3-FOXO1 POSITIVE RHABDOMYOSARCOMA

    Co-Author: Pushpendra Kumar Sahu, PhD (he/him/his) – UCSF

    Co-Author: Kristen Kwong, n/a – UCSF

    Co-Author: Yue Pan, n/a – UCSF

    Author: Amit Sabnis, MD – UCSF

  • 11:30 AM – 1:00 PM  
    GENOMIC EVOLUTION OF RESISTANCE IN GASTROINTESTINAL STROMAL TUMOR: KIT AP/AL MUTATIONS ARE A KEY MECHANISM OF KINASE-INHIBITOR ESCAPE

    Author: Sebastian Bauer, MD (he/him/his) – Department of Medical Oncology, West German Cancer Center, University Hospital Essen

    Co-Author: Johanna Falkenhorst, MD (she/her/hers) – Department of Medical Oncology, West German Cancer Center, University Hospital Essen

    Co-Author: Tom Schulz, M.Sc. – TU Dortmund University

    Co-Author: Benjamin S. Fletcher, BA – The West German Cancer Centre, University Hospital Essen

    Co-Author: Alina Teuber, M.Sc. – TU Dortmund University

    Co-Author: Dawid Krzeciesa, M.Sc. – The West German Cancer Centre, University Hospital Essen

    Co-Author: Isabella Klooster, BS – Brigham and Women's Hospital

    Co-Author: Meijun Lundberg, MD – Brigham and Women's Hospital

    Co-Author: Lydia Wilson, BS – Dana-Farber Cancer Institute

    Co-Author: Jonas Lategahn, PhD – TU Dortmund University

    Co-Author: Margaret von Mehren, MD (she/her/hers) – Fox Chase Cancer Center

    Co-Author: Susanne Grunewald, PhD (she/her/hers) – West German Cancer Center, University Hospital Essen

    Co-Author: Alicia I. Tüns, M.Sc. – University Hospital Essen

    Co-Author: Eva Wardelmann, MD (she/her/hers) – Institute of Pathology,.University Hospital Muenster

    Co-Author: Jason K. Sicklick, M.D., FACS – Department of Surgery, Division of Surgical Oncology, University of California San Diego

    Co-Author: Mehdi Brahmi, MD PhD – CENTRE LEON BERARD AND CANCER RESEARCH CENTER OF LYON (INSERM U1052-CNRS5286)

    Co-Author: César Serrano, MD, PhD – Medical Oncology Department, Hospital Universitario Vall d'Hebron, Vall d'Hebron Institute of Oncology, Barcelona, Spain

    Co-Author: Hans-Ulrich Schildhaus, MD – Institute of Pathology, West German Cancer Center, University Hospital Essen

    Co-Author: Sonja Sievers, PhD – Compound Management and Screening Center, Max Planck Institute of Molecular Physiology

    Co-Author: Jürgen Treckmann, MD – University Hospital Essen

    Co-Author: Michael C. Heinrich, MD – Portland VA Health Care System and Oregon Health & Science University Knight Cancer Institute

    Co-Author: Chandrajit P. Raut, MD, MSc, FACS, FSSO (he/him/his) – Brigham and Women’s Hospital/Harvard Medical School

    Co-Author: Wen-Bin Ou, PhD (he/him/his) – Brigham and Women's Hospital

    Co-Author: Adrian Marino-Enriquez, MD, PhD – Brigham and Women's Hospital and Harvard Medical School

    Co-Author: Suzanne George, MD – Dana-Farber Cancer Institute

    Co-Author: Daniel Rauh, PhD – TU Dortmund University

    Co-Author: Jonathan A. Fletcher, MD – HarvardMedical School/Brigham and Women's Hospital

    Co-Author: Thomas Muehlenberg, PhD (he/him/his) – The West German Cancer Centre, University Hospital Essen

  • 11:30 AM – 1:00 PM  
    PRE-CLINICAL ACTIVITY OF ADCT-601, AN ANTIBODY-DRUG CONJUGATE TARGETING AXL IN SOFT-TISSUE SARCOMA

    Author: Nathan EL-GHAZZI, Resident (he/him/his) – Institut Bergonié INSERM BRIC U1312

    Co-Author: Tony Sourisseau, PhD – Institut Bergonié INSERM BRIC U1312

    Co-Author: Antoine Italiano, MD,PhD – Institut Bergonié

  • 11:30 AM – 1:00 PM  
    A NOVEL SYSTEMS BIOLOGY APPROACH FOR IDENTIFICATION AND VALIDATION OF NON-GENETICALLY ENCODED VULNERABILITIES IN PEDIATRIC SARCOMA.

    Author: Filemon S. Dela Cruz, MD (he/him/his) – Memorial Sloan Kettering Cancer Center

    Co-Author: Prabhjot S. Mundi, M.D. – Department of Medicine, Columbia University

    Co-Author: Glorymar Ibanez Sanchez, BS – Memorial Sloan Kettering Cancer Center

    Co-Author: Kristina Guillan, BS (she/her/hers) – Memorial Sloan Kettering Cancer Center

    Co-Author: Armaan Siddiquee, MS – Memorial Sloan Kettering Cancer Center

    Co-Author: Andrea Califano, PhD – Department of Systems Biology, Biomedical Informatics, Biochemistry and Molecular Biophysics, and Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University

    Co-Author: Andrew L. Kung, MD, PhD – Memorial Sloan Kettering Cancer Center

  • 11:30 AM – 1:00 PM  
    MTA-COOPERATIVE PRMT5 INHIBITORS ARE EFFICACIOUS IN MTAP-DELETED MALIGNANTPERIPHERAL NERVE SHEATH TUMOR MODELS

    Author: Xiaochun Zhang, MD – Washington University in St. Louis

    Co-Author: Dana C. Borcherding, PhD – Washington University in St. Louis

    Co-Author: Minjie Zhang, PHD – Tango Therapeutics

    Co-Author: Himanshi Bhatia, PHD (she/her/hers) – Washington University

    Co-Author: Yang Lyu, PhD – Washington University in St. Louis

    Co-Author: Kuangying yang, MS – Washington University

    Co-Author: Kevin He, BS – Washington University in St. Louis

    Co-Author: Liuzhang yang, PHD – Washington University

    Co-Author: Heather DiBenedetto, MS – Tango Therapeutics

    Co-Author: Kimberly Briggs, PHD – Tango Therapeutics

    Co-Author: Alice Tsai, PHD – Tango Therapeutics

    Co-Author: Alan Huang, PHD – Tango Therapeutics

    Co-Author: John Maxwell, PHD – Tango Therapeutics

    Co-Author: Kevin Cottrell, PHD – Tango Therapeutics

    Co-Author: Angela Hirbe, MD,PHD – Washington University in St. Louis

  • 11:30 AM – 1:00 PM  
    EVALUATION OF THE MASSPEC PEN TECHNOLOGY FOR MOLECULAR IDENTIFICATION OF BONE AND SOFT TISSUE SARCOMAS AND SURGICAL MARGIN ASSESSMENT

    Author: Keila E. Torres, MD, PhD, MBA, FACS (she/her/hers) – The University of Texas MD Anderson Cancer Center

    Presenter: Ashley Montgomery, MD Candidate 2026 – Baylor College of Medicine

    Co-Author: Justin Bird, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Sharon Landers, PhD – The University of Texas MD Anderson Cancer Center

    Co-Author: Douglas Fletcher, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Sintawat Wangsiricharoen, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Patrick Lin, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Valerae Lewis, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Bryan Moon, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Robert L. Satcher, Jr., MD PhD – The University of Texas MD Anderson Cancer Center

    Co-Author: Spencer Frink, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Shalin Shreyaskumar Patel, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Christopher Scally, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Emily Z. Keung, MD, AM, FACS – The University of Texas MD Anderson Cancer Center

    Co-Author: Christina Roland, MD, MS (she/her/hers) – The University of Texas MD Anderson Cancer Center

    Co-Author: Kelly Hunt, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Ian McCutcheon, MD – The University of Texas MD Anderson Cancer Center

    Co-Author: Wei-Lien Wang, M.D – The University of Texas MD Anderson Cancer Center

    Co-Author: Wendong Yu, MD, Ph.D – The University of Texas MD Anderson Cancer Center

    Co-Author: Livia Eberlin, Ph.D – Baylor College of Medicine

  • 11:30 AM – 1:00 PM  
    POST-OPERATIVE MINIMAL RESIDUAL DISEASE MODELS TO STUDY METASTATIC RELAPSE IN SOFT-TISSUE SARCOMA PATIENT-DERIVED XENOGRAFTS

    Author: Suzanne Fischer, MD (she/her/hers) – Ghent University

    Co-Author: David Creytens, M.D. – Ghent University Hospital

    Co-Author: Sofie De Geyter, Ms – Ghent University

    Co-Author: Stefanie Gijsels, MD (she/her/hers) – Ghent University

    Co-Author: Elly De Vlieghere, dr. – Ghent University

    Co-Author: Piet Pattyn, M.D. – Ghent University Hospital

    Co-Author: Sarah-Lee Beaert, ms – Ghent University

    Co-Author: Kaat Durinck, dr. – Ghent University

    Co-Author: Nadine Van Roy, M.D. – Ghent University

    Co-Author: An Hendrix, dr – Ghent University

    Co-Author: Lore Lapeire, M.D. – Ghent University Hospital

    Co-Author: Gwen ML Sys, MD, PhD (she/her/hers) – Ghent University Hospital