(P 77) PATIENT OUTCOMES AFTER OPEN VERSUS CORE NEEDLE BIOPSY IN LOWER EXTREMITY SARCOMA

Objective: There are limited data evaluating how the type of biopsy impacts definitive surgical resection or postoperative outcomes in bone sarcomas. The aims of this study were to (1) characterize current biopsy practice patterns, and (2) evaluate how biopsy type impacts outcomes.

Methods: This study was a preplanned secondary analysis of the prospective, multicenter PARITY (Prophylactic Antibiotic Regimens in Tumor Surgery) study. Patients with a benign diagnosis, metastatic disease, or no biopsy prior to surgery were excluded. Parametric and nonparametric tests were used to compare variables between groups, and the Cox proportional hazards method was used to compare infection-related and oncological outcomes at 1 year. Median functional outcome scores at 1 year were compared.

Results: In total, 464 patients met inclusion criteria from 48 sarcoma centers in 12 countries. CNB was used in 57.5% of cases. OB was more common in the U.S. and Canada. Median operative time was significantly longer after OB (324 versus 260 minutes; p < 0.001). In the OB group, significantly more skin (p < 0.001) and fascial tissue (p < 0.001) were excised with a lower rate of primary closure (86.3% versus 92.9%; p = 0.03). There were no differences in surgical site infection or oncological outcomes between the groups.

Conclusion: CNB was used most commonly overall. OB was more common in the U.S. and Canada. Patients undergoing OB had longer operative times, more excised tissue, and lower rates of primary closure. There were no differences in infection rates or oncological outcomes, including local recurrence.